Protein kinase Cα as a heart failure therapeutic target
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چکیده
منابع مشابه
Protein kinase C in heart failure: a therapeutic target?
Heart failure (HF) afflicts about 5 million people and causes 300,000 deaths a year in the United States alone. An integral part of the pathogenesis of HF is cardiac remodelling, and the signalling events that regulate it are a subject of intense research. Cardiac remodelling is the sum of responses of the heart to causes of HF, such as ischaemia, myocardial infarction, volume and pressure over...
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HEART FAILURE, THE ULTIMATUM of various forms of myocardial disease, is associated with high mortality rate in this modern world (2). Multiple factors play important roles in the genesis of heart failure. The presence of left ventricular hypertrophy is a powerful predictor of the development of heart failure (3). It is believed that gradual deterioration of the hypertrophied left ventricle (LV)...
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Heart failure is a pressing public health problem with no curative treatment currently available. The existing therapies provide symptomatic relief, but are unable to reverse molecular changes that occur in cardiomyocytes. The mechanisms of heart failure are complex and multiple, but mitochondrial dysfunction appears to be a critical factor in the development of this disease. Thus, it is import...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2011
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2010.10.004